David Wheeler scored a 90th-minute winner for Wycombe Wanderers as MK Dons suffered their first defeat of the 2019/20 season.
The Chairboys opened the scoring from the penalty spot but Jordan Bowery equalised with his first goal for the Club.
Wycombe struck again through Onyendinma - a goal which was cancelled out in the second half by Jordan Houghton’s penalty.
The home side, though, would go on to secure a 3-2 victory courtesy of a late goal from former MK Dons loanee Wheeler.
Boss Tisdale made three changes to the side which beat AFC Wimbledon on penalties in midweek, with George Williams, Jordan Houghton and Hiram Boateng returning to the starting XI while Regan Poole retained his place in defence.
Rhys Healey was back amongst the substitutes after being rested in midweek while there was a spot for David Kasumu, who impressed in the Carabao Cup triumph.
MK Dons started brightly with Dean Lewington whipping a cross into the box early on for Jordan Bowery - the striker, though, couldn’t connect.
Wycombe responded and went within a whisker of breaking the deadlock on six minutes when Fred Onyedinma met a cross with an acrobatic effort. His shot was on target but was pushed around the post by a fingertip save from Lee Nicholls.
Joe Jacobson struck the wall with a ninth-minute free-kick as the home side threatened once again.
They were presented the perfect opportunity to break the deadlock two minutes later as Paul Smyth went down under the challenge of Jordan Houghton. Jacobson stepped up to take the spot kick and cooly slotted his effort down the middle for the opening goal. 1-0.
Agard went close to restoring parity with a near-post header from Boateng’s free-kick on 14 minutes. Dean Lewington also threatened with a low right-footed shot which Ryan Allsop gathered.
The Dons’ best chance of the opening 25 minutes fell to Bowery, who did well to race onto a long ball forward from Cargill but couldn’t beat Allsopp with his strike.
With half an hour on the clock, Onyedinma flashed a free-kick past the post from 25-yards out. Then Bowery had another opportunity on goal - and this time he made no mistake.
The Dons did well down the left to create room for Cargill to deliver a low cross. His ball was inch-perfect and slid right through to Bowery, who had the simplest of finishes to level the scores. 1-1.
Shortly after the re-start, Nicholls kept out an Onyedinma strike shortly before Gape denied Poole with a clearance on the line from the defender’s stabbed effort, moments after the Welshman had seen a low shot saved by Allsop.
Wycombe then restored their lead through Onyedinma, who latched onto a pass from Samuel and drilled a low left-footed shot beyond Nicholls into the far corner. 2-1.
It looked as through the Chairboys would see their lead out through to the break and they did, despite the Dons being awarded a penalty late in stoppage time - Lewington the man fouled. McGrandles stepped to take the spot kick but couldn’t keep his effort down.
The Dons, determined not to let the late drama affect them, started the second half well and Bowery forced a save out of Allsop at his near post within three minutes of the re-start. From the resulting corner, Martin headed wide.
Playing towards the 1,130 travelling MK Dons supporters, Tisdale’s men continued to push for an early equaliser and they were handed another opportunity to do so from the penalty spot on 50 minutes when Jacobson bundled into the back of Agard.
Houghton, this time, took responsibility and he converted - rifling his right-footed shot into the back of the net from 12-yards. 2-2.
Cargill almost made it three soon after with a left-footed volley which Allsop did well to divert over the crossbar with his fingertips.
Tisdale made his first substitution on 64 minutes, replacing Boateng with Alex Gilbey. He was involved right away, winning a corner from which Martin fired over the crossbar.
Wycombe introduced former Dons loanee David Wheeler in the same minute and Martin had to be on guard to turn his low cross behind with a Wycombe man lurking, awaiting a tap in.
The Dons, though, were pushing forward with real intent and they had another shout for a penalty on 70 minutes for a handball but referee Trevor Kettle, this time, waved away appeals. Lewington then had a try from the edge of the area but couldn’t find the target.
Healey entered the fray with 17 minutes to play but it was Adebayo Akinfenwa, a Chairboys subsitute, who wasted a glorious chance moments after coming on - he looked, for all the world, to be tapping in Onyedinma’s cross but failed to connect with the ball inside the six-yard box.
Nick Freeman blasted wide as the hosts went close again before Pattison rifled one over the crossbar from 25-yards.
It was Wycombe in the ascendancy as the clock wound down and in the final minute of regulation time they took the lead for a third time - Wheeler the man on target, against his former club, firing home a low shot from the right-hand side of the box. 3-2.
Starting XI: Nicholls, Williams, Lewington (c) (Brittian 90), Poole, Cargill, Bowery, Agard (Healey 73), Martin, McGrandles, Houghton, Boateng (Gilbey 64).
Unused subs: Moore, Nombe, Kasumu, Harley.
Goals: Bowery (31), Houghton (pen 51)
Referee: T Kettle
Attendance: 5,243 (1,130 away)