Luke Chadwick and Daniel Powell both return to the starting XI for the first time since November as Karl Robinson makes three changes to his side.
With Dele Alli ruled out through injury and loanee Chris Long ineligible to play, Chadwick and Powell both come into the side with the latter occupying a long strikers role. Chadwick will play in the middle of an attacking trio, alongside Ben Reeves and Samir Carruthers.
The other change of the evening sees Northern Ireland international Lee Hodson come into the starting XI in place of George Baldock.
MK Dons (4-2-3-1): Martin; Hodson, Kay, Williams, Lewington (c); Potter, Gleeson; Reeves, Chadwick, Carruthers; Powell.
Subs: McLoughlin (GK), Flanagan, Bowditch, Smith, McLeod, Baldock, Galloway.
Wigan Athletic: Al Habsi, Crainey, McCann, Watson, McClean, McArthur, Espinoza, Fyvie, Perch, Barnett, Fortune.
Subs: Nicholls, Gomez, Boyce, Powell, Beausejour, Garcia, Redmond
