Karl Robinson makes two changes to the starting XI, with Antony Kay and Dele Alli coming into the side to replace Jordan Spence and Dale Jennings.
Spence hasn’t travelled with the team with his loan deal set to expire tomorrow meaning Kay comes into the starting XI for the first time since undergoing hip surgery in October. Alli, who has also recently been sidelined through injury, starts on the left-hand side of an attacking trio in place of Jennings, who was recalled by Barnsley on Friday.
Elsewhere, the Dons remain unchanged with Patrick Bamford leading the line up front, in what will be his last game before joining Derby County on loan next week and Samir Carruthers out on the right-hand side, with his future yet to be decided.
There is one surprise on the bench in the form of talisman Luke Chadwick who has been out of action for over a month with a foot injury. Chadwick is joined by Ian McLoughlin, Tom Flanagan, Alan Smith, Daniel Powell, George Baldock, Brendan Galloway on the bench.
Wigan Athletic: Al Habsi, Boyce (c), Perch, Barnett, Espinoza, McArthur, Gomez, McManaman, Holt, McClean, Beausejour.
Subs: Pollitt (GK), Dicko, Fortune, Fyvie, Redmond, McCann, Crainie.
MK Dons (4-2-3-1): Martin; Hodson, Kay, Williams, Lewington (c); Potter, Gleeson; Carruthers, Reeves, Alli; Bamford.
Subs: McLoughlin (GK), Flanagan, Chadwick, Smith, Powell, Baldock, Galloway.