Mark Randall is handed his first start since returning to MK Dons while Izale McLeod replaces James Loveridge up-front after scoring last weekend.
Randall, who re-joined the Club on a short-term deal in March, will play alongside Dele Alli and Alan Smith in midfield. McLeod, meanwhile, will be the centre-piece in an attacking trio between Matty Kennedy and Daniel Powell.
The only other change to the starting XI sees youngster Brendan Galloway step in at centre-back in place of Antony Kay, who misses out due to a thigh injury.
On the bench, Sanmi Odelusi returns following a one-match suspension while Ryan Hall is declared fit after recovering from an ankle injury.
MK Dons: Martin; Baldock, Spence, Galloway, Lewington (c); Alli, Smith, Randall; Kennedy, McLeod, Powell.
Subs: Burns (GK), Rasulo, Hall, Loveridge, Odelusi.
Crawley Town: Jones, Sadler, McFadzean, Drury, Simpson (c), Walsh, Proctor, Bulman, Jones, Dicker, P Connolly.
Subs: Maddison (GK), M Connolly, Torres, Fallon, Tubbs, Monakana, Edwards.
Referee: Stephen Bratt (West Midlands)