Karl Robinson hands loanee Jordan Spence a start at the back, alongside Shaun Williams who returns from suspension.
Spence joined the Club on a 28-day loan on Thursday but goes straight into a back four which also contains Williams, Jon Otsemobor and Dean Lewington. Ian McLoughlin is the goalkeeper with David Martin out injured.
In midfield, Ben Reeves will once again partner Darren Potter with Stephen Gleeson still unavailable with a calf injury. Reeves and Potter will play behind an attacking trio of Daniel Powell, Jason Banton and Luke Chadwick, who makes his first start since picking up a foot injury, while country's leading goalscorer, Patrick Bamford, is the lone striker.
On the bench for the Dons this afternoon are Tom Flanagan, Lee Hodson, Alan Smith, Izale McLeod, George Baldock, Samir Carruthers and Under-18s goalkeeper Charlie Burns.
Tranmere Rovers: Fon Williams, Holmes, Taylor, Hateley, Lowe (c), Baggie, Atkinson, Kirby, Power, McNulty, Ridehalgh.
Subs: Watkins (GK), Horwood, Rowe, Stockton, Jennings, Sodje, Koumas.
MK Dons (4-2-3-1): McLoughlin; Otsemobor, Spence, Williams, Lewington (c); Potter, Reeves; Powell, Chadwick, Banton; Bamford.
Subs: Burns (GK), Flanagan, Hodson, Smith, McLeod, Baldock, Carruthers.