MK Dons boss Karl Robinson is forced into making three changes to his side due to injuries and suspensions.
The Dons will be without David Martin, Stephen Gleeson and Shaun Williams, as confirmed by the manager on Monday. Martin (calf) and Gleeson (calf) both miss out through injury while Williams is suspended having collected his fifth booking of the campaign on the weekend.
Coming in to replace the trio are Ian McLoughlin, who will play in goal; Samir Carruthers, who will play in the number 10 position alongside Daniel Powell and Jason Banton; and Lee Hodson, who will play at right-back, with Jon Otsemobor moving into the centre. Ben Reeves, who played in the attacking trio on the weekend, will partner Darren Potter in centre midfield.
Despite the lengthy absentee list, Robinson is able to name seven substitutes, one of which is talisman Luke Chadwick, who returns from a foot injury. Chadwick will be joined on the bench by Alan Smith, Izale McLeod, George Baldock and Academy trio Charlie Burns, Brendan Galloway and Giorgio Rasulo.
MK Dons (4-2-3-1): McLoughlin; Hodson, Otsemobor, Flanagan, Lewington (c); Potter, Reeves; Powell, Carruthers, Banton; Bamford.
Subs: Burns (GK), Chadwick, Smith, McLeod, Baldock, Galloway, Rasulo.
Carlisle United: Gillespie, Townsend, Robson, Amoo, Noble, Thirlwell (c), Potts, O'Hanlon, Guy, McSweeney, Chimbonda.
Subs: Fleming (GK), Livesey, Miller, Gillies, Beck, Symington, Eccleston.