Karl Robinson is forced into making one change to the team that beat Tranmere Rovers on Saturday afternoon.
With Dean Lewington missing out due to a knee injury, Jon Otsemobor comes in at right-back with Adam Chicksen moving across to the left. Elsewhere, though, the Dons remain unchanged.
Ian McLoughlin once again deputises for the injured David Martin, who suffered a re-occurrence of a back complaint in training yesterday. McLoughlin is in search of his fourth clean-sheet in seven eight games.
Patrick Bamford, still awaiting his first goal for the Club since joining on loan from Chelsea, continues on the right-hand side of a front three while Stephen Gleeson is fit enough to start for the second consecutive game in the ‘number 10’ role. Gleeson will also wear the captain's armband in Lewington's absence.
Ryan Lowe gets the nod up-front with Izale McLeod and Alan Smith amongst the replacements while George Baldock is also named on the bench, looking to make an appearance following his cameo on the weekend.
MK Dons (4-2-3-1): McLoughlin; Otsemobor, Kay, Williams, Chicksen (c); Potter, Lines; Bamford, Gleeson, Bowditch; Lowe.
Subs: Kouo-Doumbe, Smith, McLeod, Baldock.
Crewe Alexandra: Phillips, Davis, Ellis, Murphy (c), Pogba, Leitch-Smith, Mellor, Robertson, Osman, Colclough, Ellington.
Subs: Martin (GK), Tootle, Dugdale, Turton, West, Aneke.
Tim Robinson (West Sussex)Referee: