Karl Robinson makes three changes to the side that drew 1-1 with Portsmouth on Tuesday.
Into the team come trio Jon Otsemobor, Chris Lines and Ryan Lowe who replace Gary MacKenzie, Ryan Harley and Izale McLeod respectively.
Otsemobor will take up his place right-back while Adam Chicksen moves into the left-wing position that he has impressed in on several occasions this season.
Shaun Williams will drop back into the centre of defence in order to replace Gary MacKenzie, allowing loanee Lines taking his spot alongside Darren Potter. The only other change sees Izale McLeod replaced by Ryan Lowe up front.
On the bench, there is a place for the returning Dean Bowditch, who has missed the last two games with a groin injury, as well as McLeod Giorgio Rasulo, Tom Flanagan, Mathias Kouo-Doumbe and George Baldock.
MK Dons (4-2-3-1): McLoughlin; Otsemobor, Kay, Williams, Lewington (c); Potter, Lines; Powell, Chadwick, Chicksen; Lowe.
Subs: Kouo-Doumbe, Bowditch, McLeod, Flanagan, Baldock, Rasulo.
Preston North End: Rudd, Buchanan, Huntington, Wright, Connolly, Hayhurst, Welsh (c), Wroe, Holmes, King, Beavon.
Subs: Stuckmann (GK), Robertson, Beardsley, Monakana, Mousinho, Proctor, Garner
Tony Bates (Staffordshire)Referee: