Midfielder Harley, who joined the Dons on loan from Brighton & Hove Albion on Monday, replaces Dele Alli in midfield while Angelo Balanta comes in for Alan Smith in the only other change to the side that lost to Coventry City last weekend.
Balanta, who will return to parent club QPR tomorrow upon the completion of his loan spell, will play on the left-hand side of an attacking trio alongside Daniel Powell and Dean Bowditch, who starts in the ‘number 10’ role behind Ryan Lowe who is passed fit after coming off early in the defeat to the Sky Blues.
Elsewhere, the Dons remain unchanged with Adam Chicksen keeping his place at right-back in the absence of Jon Otsemobor.
Notts County: Bialkowski, Kelly, Bishop (c), M Smith, Liddle, Judge, Hughes, Campbell-Ryce, Boucaud, Stewart, Iwelumo.
Subs: Spiess (GK), Showunmi, Zoko, Mahon, Arquin, Labadie, Bencherif.
MK Dons (4-2-3-1): Martin; Chicksen, Kay, Williams, Lewington (c); Potter, Harley; Powell, Bowditch, Balanta; Lowe.
Subs: McLoughlin (GK), Kouo-Doumbe, MacKenzie, MacDonald, A Smith, Alli, Ismail.
Referee: G Salisbury.