Antony Kay and Ryan Lowe come straight back into the starting XI as Karl Robinson makes four changes.
Kay, who served the final game of his four-match suspension last weekend, partners Gary MacKenzie in the centre of defence while Lowe replaces the banned Alan Smith up front. The Dons' two other switches see loanee Chris Lines replace the injured Dean Bowditch and Adam Chicksen replace Jon Otsemobor.
There is also a re-shuffle of positions as Chicksen moves to right-back in place of Jon Otsemobor, Lines joins Potter in the centre of midfield and Luke Chadwick, Shaun Williams and Ryan Harley form an attacking trio behind Lowe.
Striker Izale McLeod, who was cup-tied for the defeat to Barnsley last Saturday, is amongst the substitutes for the Dons while 'keeper Ian McLoughlin makes a return after completing his loan spell at Walsall. Daniel Powell is also deemed fit enough to take a place amongst the replacements after struggling with a knock this week.
Gillespie, Simek, Livesey, O'Hanlon, Mustoe, Noble, Thirlwell, Berrett, McGovern, Miller (c), Loy.Carlisle United:
Collin (GK), Murphy, Welsh, Cadamarteri, Potts, Beck, Symington.Subs:
Martin; Chicksen, MacKenzie, Kay, Lewington (c); Potter, Lines; Chadwick, Williams, Harley; Lowe.MK Dons (4-2-3-1):
McLoughlin, Subs:Otsemobor, Kouo-Doumbe, McLeod, Powell, Baldock, Rasulo.
Kevin Wright (Cambridgeshire)Referee: