Dean Lewington returns to the side this afternoon having missed the last four weeks with a knee injury.
The Dons skipper has been out of action since the opening day draw at Shrewsbury Town but returns to the starting line-up this afternoon in place of Ben Reeves.
Lewington is joined at the back by Shaun Williams and Antony Kay, both of whom started the Capital One Cup tie at Sunderland on Tuesday, and right-back Lee Hodson, who replaces George Baldock at right-back. Goalkeeper David Martin also returns for the Dons.
Further forward in midfield, Stephen Gleeson and Darren Potter continue their midfield partnership with the latter replacing youngster Dele Alli. Jason Banton also comes back into the side but the rest of the Dons' attacking quartet stays the same, with Patrick Bamford, Samir Carruthers and Izale McLeod all keeping their place.
On the bench for the Dons are Ian McLoughlin, Jon Otsemobor, Luke Chadwick, Alan Smith, Ben Reeves, Dele Alli and George Baldock.
Sheffield United: Long, Maguire, Hill, Flynn, Doyle, Taylor, Baxter, Collins, Coady, Murphy, McMahon.
Subs: Howard (GK), Westlake, McGinn, Brandy, McGinty, Ironside, McFadzean.
MK Dons (4-2-3-1): Martin; Hodson, Kay, Williams, Lewington (c); Potter, Gleeson; Banton, Bamford, Carruthers; McLeod.
McLoughlin (GK), Otsemobor, Chadwick, Smith, Reeves, Alli, Baldock.Subs: