Dons boss Karl Robinson has made three changes to the side that drew 0-0 with Shrewsbury Town last weekend.
Youngsters George Baldock, Patrick Bamford and Ben Reeves have all played their way into the side following their impressive displays in the mid-week Capital One Cup victory over Northampton Town, with the Luke Chadwick, Alan Smith and the injured Dean Lewington making way for the trio.
Baldock will line up on the right-hand side of an attacking trio alongside 17-year-old Dele Alli, who starts his third successive game, and loanee Jason Banton, who opened his Dons account on Tuesday night. Bamford will lead the line up front, making the average of Dons’ attacking quartet only 19.
Reeves, who also scored his first goal for the Club against Northampton Town, will start at left-back in place of Dean Lewington, who failed a late fitness test on an injured knee. Reeves will be accompanied by Lee Hodson, Antony Kay and Shaun Williams in defence.
Elsewhere, David Martin returns in goal and Stephen Gleeson and Darren Potter reunite their midfield partnership.
On the bench for the Dons are Ian McLoughlin, Jon Otsemobor, Tom Flanagan, Luke Chadwick, Alan Smith, Izale McLeod and new-signing Samir Curruthers, who completed a loan switch to stadiummk hours ago and has received clearance from the Football League and the FA to play.
MK Dons (4-2-3-1): D Martin; Hodson, Kay, Williams, Reeves; Potter, Gleeson (c); Baldock, Alli, Banton; Bamford.
Subs: McLoughlin (GK), Otsemobor, Flanagan, Chadwick, Smith, McLeod, Curruthers.
Crewe Alexandra: A Martin; Tootle, Mellor, Davis, Clayton, Osman (c), Leitch-Smith, Ray, Aneke, Colclough, Grant.
Phillips (GK), Ellis, Dugdale, Robertson, Oliver, Turton, West.Subs: