Karl Robinson makes two changes to the side that beat Swindon Town 2-0 on Tuesday evening, with Stephen Gleeson ruled out through injury.
The Irish midfielder picked up a knock to his ankle in the important win earlier this week and, having been closely monitored since Tuesday, he has been deemed unfit to play this afternoon. His absence allows Chris Lines to come back into the side to partner Darren Potter in midfield, with the loanee still in search of his first goal for the Club.
The only other change sees Ryan Lowe, who scored from the bench in the victory over the Robins, replace Luke Chadwick in the ‘number 10’ role, with the former Manchester United man dropping to the bench. Lowe will play alongside Bowditch and Adam Chicksen in attacking three behind Patrick Bamford.
Elsewhere the Dons remain unchanged, with a back-four of Jon Otsemobor, Mathias Kouo-Doumbe, Shaun Williams and Dean Lewington in search of a fifth-straight clean-sheet. Ian McLoughlin is the goalkeeper once again, with David Martin missing through injury.
On the bench, Robinson has six replacements available to him, which include Chadwick, Alan Smith, Izale McLeod, George Baldock, Daniel Powell and Antony Kay.
Gleeson (ankle) and Martin (back) are the only absentees.
Leyton Orient: Jones, McSweeney, Sawyer, Vincelot, Cox, Lisbie, J Smith, MacDonald, Clarke (c), Odubajo, Rowlands.
Subs: Butcher (GK), Obafemi, Cook, James, Lee, Vanderhyde.
MK Dons (4-2-3-1): McLoughlin; Otsemobor, Kouo-Doumbe, Williams, Lewington (c); Potter, Lines; Bowditch, Lowe, Chicksen; Bamford.
Subs: Smith, McLeod, Baldock, Powell, Kay, Chadwick.
Andy D’Urso (Essex)Referee: