Karl Robinson makes five changes to the side that beat Carlisle United on Saturday and hands midfielder Jimmy Bullard his full Dons debut.
Antony Kay and Alan Smith return to the side after their suspensions, the former partnering Shaun Williams in the centre of defence.
Stephen Gleeson retains the captain’s armband in place of Dean Lewington who serves the final game of his three-match suspension which means there is another start for Adam Chicksen at left-back.
Under-18 captain Mason Spence is also handed a start at right-back in place of Jon Otsemobor who is rested along with Darren Potter while Gary MacKenzie has linked up with his international teammates after being called up by Scotland yesterday.
Northampton Town also make five changes to the side that were beaten 3-2 by Plymouth Argyle on Saturday, including the exclusion of former-Don Ben Harding.
Aidy Boothroyd brings in Ishmel Demontagnac for his first start of the season and the same goes for centre-back Antony Charles. There is also a place on the bench for youth player Claudio Dias.
Northampton Town (4-4-2): L Nicholls; East, Langmead (c), Charles, Widdowson; Demontagnac, Tozer, Moult, Robinson; Akinfenwa, Mukendi.
Subs: Snedker, A Nicholls, Wilson, Turnbull, Dias.
MK Dons (4-3-3): Martin; Spence, Kay, Williams, Chicksen; Smith, Gleeson (c), Bullard; Powell, MacDonald, Bowditch.
Subs: Lowe, Ibehre, Galloway, O'Shea, Chadwick.