MK Dons boss Karl Robinson makes two changes to the side that drew 0-0 with Cambridge City, with both Dean Bowditch and Angelo Balanta returning to the starting XI.
Bowditch has missed the last four games with a knock picked up in training but he takes his place on the right-hand side of a front three alongside Luke Chadwick and Balanta, who is available after sitting out last Friday’s Cup tie due to the terms of his loan.
Elsewhere, Ryan Lowe is given the nod up front while fellow strikers Charlie MacDonald and Alan Smith take up places on the bench having recovered from illness and injury respectively.
20-year old Ibra Sekajja, who joined the Club on loan from Crystal Palace this afternoon, is also among the substitutes along with youngster Dele Alli who impressed in Friday night's cup tie.
MK Dons (4-2-3-1): Martin; Otsemobor, Kay, Williams, Lewington (c); Gleeson, Potter; Bowditch, Chadwick, Balanta; Lowe.
Subs: McLoughlin, Kouo-Doumbe, MacDonald, A Smith, Chicksen, Alli, Sekajja.
Leyton Orient: Allsop; Sawyer, Chorley, Griffith, Clarke (c), Odubajo, Cook, Rowlands, James, Wagstaff, Mooney.
Subs: Jones (GK), McSweeney, Baudry, Cox, Lisbie, J Smith, Brunt.
Referee: R Lewis (Shropshire)