Stephen Gleeson returns after his three-match ban and will wear the captain’s armband in the absence of the suspended Dean Lewington.
Shaun Williams starts for the first time since recovering from injury at the back in place of Dean Lewington following his dismissal on Saturday.
Charlie MacDonald is given the nod up top in place of Ryan Lowe with Daniel Powell, Luke Chadwick and Dean Bowditch providing support.
MK Dons (4-2-3-1): Martin; Otsemobor, MacKenzie, Williams, Chicksen; Potter, Gleeson (c); Powell, Chadwick, Bowditch; MacDonald.
Subs: McLoughlin, Lowe, Ibehre, Alli, Galloway.
Blackburn Rovers: Kean, Orr, Nunes, Marcus Olsson, Dann (c), Jorge, Etuhu, Junior, Rochina, Hanley, Vukcevic.
Subs: Formica, Lowe, Martin Olsson, Goodwillie, Morris, Usai, Ribeiro.