With Gary MacKenzie still injured, Antony Kay and Shaun Williams continue their partnership in the centre of defence in between Jon Otsemobor and Dean Lewington.
The only difference from Tuesday night is the absence of Ryan Lowe, who is ill.
MK Dons (4-2-3-1): Martin; Otsemobor, Kay, Williams, Lewington (c); Gleeson, Potter; Powell, Chadwick, Bowditch; MacDonald.
Subs: McLoughlin (GK), Kouo-Doumbe, Smith, Chicksen, O’Shea, Allan.
Portsmouth (4-4-2): Anderson; Dumbuya, Michalik, Gyepes, Webster; Williamson, Ertl, Howard (c), Harley; Thomas, McLeod.
Subs: Eastwood (GK), Walker, Rodgers, Compton, Obita, Buzsaky, Harris.
Referee: David Coote (Nottinghamshire)